Study Comparing Weekly Taxol and Carboplatin vs Standard Taxol and Carboplatin Regimen for Stage IIIB or IV Non-Small-Cell Lung Cancer

Completed · Phase 3

Conditions studied: Carcinoma, Non-Small-Cell Lung

In brief

Taxol and carboplatin are commonly used drugs for the treatment of stage IIIB or IV non small cell lung carcinoma. This study compares treatment with Taxol/carboplatin given every 3 weeks to a schedule where it is given weekly. The purpose of the study is to determine the most effective and safe schedule for giving these drugs in non small cell lung carcinoma.

Key facts

Study ID

NCT00035152

Run by

Bristol-Myers Squibb

People needed

444

Starts

2000-06-01

Expected to finish

2004-12-01

Last updated by the study team

2016-09-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmation of non-small cell bronchogenic carcinoma (epidermoid, squamous, adeno, large cell anaplastic carcinoma, but no small cell or carcinoid) must be histologically or cytologically confirmed.
• No prior antineoplastic chemotherapy, hormonal therapy or therapy with biological response modifiers
• No previous irradiation to the only area of measurable disease.

You may not qualify if…

• Past or current history of neoplasm other than the entry diagnosis. Exceptions are curatively treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix or other cancers treated by surgery or radiation with a disease free survival longer than 5 years.
• Patients who have undergone surgery less than 3 weeks prior to enrollment.
• History of serious cardiac disease not adequately controlled.
• Patients with serious active infections or other serious underlying medical condition.
• Uncontrolled diabetes mellitis.

Where it is running

• Little Rock Hematology/Oncology Associates — Little Rock, Arkansas, United States
• Highlands Oncology Group — Springdale, Arkansas, United States
• Medical Oncology Care Associates — Orange, California, United States
• Naval Medical Center — San Diego, California, United States
• Danbury Hospital/Praxair Cancer Center — Danbury, Connecticut, United States
• Walter Reed Army Hospital — Washington D.C., District of Columbia, United States
• Washington VA Medical Center — Washington D.C., District of Columbia, United States
• Good Samaritan Medical Center — West Palm Beach, Florida, United States
• Wellstar Cobb Hospital — Austell, Georgia, United States
• Joliet Oncology/Hematology Associates,Ltd. — Joliet, Illinois, United States
• Mid Illinois Hematology and Oncology Associates, Ltd. — Normal, Illinois, United States
• West Suburban Center for Cancer Care — River Forest, Illinois, United States
• Community Cancer Care, Inc. — Indianapolis, Indiana, United States
• Associated Physicians & Surgeons Clinic, LLC — Terre Haute, Indiana, United States
• Mercy Cancer Center — Mason City, Iowa, United States
• Siouxland Hematology/Oncology Associates — Sioux City, Iowa, United States
• Jewish Medical Plaza — Louisville, Kentucky, United States
• University of Louisville — Louisville, Kentucky, United States
• Louisiana Oncology Associates — Lafayette, Louisiana, United States
• Louisiana State University Health Sciences Center — Shreveport, Louisiana, United States
• Maine General Medical Center — Waterville, Maine, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Hematology and Oncology Associates of Southern Michigan,P.C — Jackson, Michigan, United States
• Hennepin County Medical Center — Minneapolis, Minnesota, United States
• Genesis Cancer Center — Hot Springs, Arkansas, United States

Full record on ClinicalTrials.gov

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