Research Study of Visilizumab for Treatment of Glucocorticoid- Refractory Graft Versus Host Disease

Status unconfirmed · Phase 2

Conditions studied: Graft-vs-Host Disease

In brief

The purpose of this phase II study is to evaluate an investigational monoclonal antibody for the treatment of glucocorticoid-refractory Graft Versus Host Disease (GVHD). Patients diagnosed with GVHD who have not responded satisfactorily to, or are intolerant of, treatment with standard agents will be considered for entry. Patients will be allowed to continue on their other immunosuppressive drugs at stable doses during the trial. The research is being conducted at up to 20 clinical research sites in the US.

Key facts

Study ID

NCT00032279

Run by

Fred Hutchinson Cancer Center

People needed

80

Starts

2002-03-01

Last updated by the study team

2005-06-24

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

Where it is running

• City of Hope National Medical Center — Duarte, California, United States
• Stanford University Medical Center — Stanford, California, United States
• H. Lee Moffitt Cancer Center & Research Institute — Tampa, Florida, United States
• University Hospital — Indianapolis, Indiana, United States
• Dana Farber Cancer Institute — Boston, Massachusetts, United States
• University of Massachusetts Medical School — Worcester, Massachusetts, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• The New York Hospital Cornell Medical Center — New York, New York, United States
• Westchester Medical Center — Valhalla, New York, United States
• Duke University — Durham, North Carolina, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• Ohio State University — Columbus, Ohio, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• Baylor University Medical Center — Dallas, Texas, United States
• Baylor College of Medicine — Houston, Texas, United States
• MD Anderson Cancer Center — Houston, Texas, United States
• Fred Hutchinson Cancer Research Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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