Melatonin and Radiation Therapy in Treating Patients With Brain Metastases

Completed · Phase 2

Conditions studied: Metastatic Cancer, Radiation Toxicity, Unspecified Adult Solid Tumor, Protocol Specific

In brief

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as melatonin may make tumor cells more sensitive to radiation therapy and may protect normal cells from the side effects of radiation therapy. PURPOSE: Randomized phase II trial to determine the effectiveness of combining melatonin with radiation therapy in treating patients who have brain metastases.

Key facts

Study ID

NCT00031967

Run by

Radiation Therapy Oncology Group

Starts

2002-05-01

Last updated by the study team

2020-10-22

Who can join

Age: any, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Comprehensive Cancer Institute of Huntsville — Huntsville, Alabama, United States
• MBCCOP - Gulf Coast — Mobile, Alabama, United States
• Alabama Oncology, LLC — Montgomery, Alabama, United States
• DCH Cancer Treatment Center — Tuscaloosa, Alabama, United States
• Foundation for Cancer Research and Education — Phoenix, Arizona, United States
• Mount Diablo Medical Center — Concord, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Saint Agnes Cancer Center — Fresno, California, United States
• California Cancer Center — Fresno, California, United States
• Sutter Health West Cancer Research Group — Greenbrae, California, United States
• Loma Linda University Medical Center — Loma Linda, California, United States
• Veterans Affairs Medical Center - Long Beach — Long Beach, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• CCOP - Bay Area Tumor Institute — Oakland, California, United States
• Huntington Cancer Center — Pasadena, California, United States
• Robert and Beverly Lewis Family Cancer Care Center — Pomona, California, United States
• Radiation Oncology Center - Sacramento — Sacramento, California, United States
• Radiation Medical Group, Incorporated — San Diego, California, United States
• UCSF Comprehensive Cancer Center — San Francisco, California, United States
• O'Connor Hospital — San Jose, California, United States
• CCOP - Santa Rosa Memorial Hospital — Santa Rosa, California, United States
• David Grant Medical Center — Travis Air Force Base, California, United States
• Memorial Hospital Cancer Center — Colorado Springs, Colorado, United States
• University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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