Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease

Completed · Phase 3

Conditions studied: Graft Versus Host Disease

In brief

RATIONALE: Hydroxychloroquine may decrease the immune response and be effective in treating chronic graft-versus-host disease. It is not yet known if standard therapy for graft-versus-host disease is more effective with or without hydroxychloroquine. PURPOSE: Randomized phase III trial to compare the effectiveness of standard therapy alone with that of standard therapy plus hydroxychloroquine in treating patients who have newly diagnosed chronic graft-versus-host disease.

Key facts

Study ID

NCT00031824

Run by

Children's Oncology Group

People needed

82

Starts

2002-04-01

Expected to finish

2011-01-01

Last updated by the study team

2014-02-14

Who can join

Age: 1 and older, up to 29. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Southern California Permanente Medical Group — Downey, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Children's Hospital Los Angeles — Los Angeles, California, United States
• University Medical Center at Princeton — Los Angeles, California, United States
• Kaiser Permanente Medical Center - Los Angeles — Los Angeles, California, United States
• Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center at UCLA — Los Angeles, California, United States
• Children's Hospital and Research Center at Oakland — Oakland, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Lucile Packard Children's Hospital at Stanford University Medical Center — Palo Alto, California, United States
• Children's Hospital and Health Center, San Diego — San Diego, California, United States
• UCSF Comprehensive Cancer Center — San Francisco, California, United States
• Presbyterian - St. Luke's Medical Center — Colorado Springs, Colorado, United States
• Children's Hospital Cancer Center — Denver, Colorado, United States
• Lombardi Cancer Center at Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• University of Florida Shands Cancer Center — Gainesville, Florida, United States
• Nemours Children's Clinic — Jacksonville, Florida, United States
• Miami Children's Hospital — Miami, Florida, United States
• All Children's Hospital — St. Petersburg, Florida, United States
• AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus — Atlanta, Georgia, United States
• MBCCOP-Medical College of Georgia Cancer Center — Augusta, Georgia, United States
• Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
• Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.