Ribavirin to Prevent RSV Pneumonia in Bone Marrow Transplant Patients

Stopped early · Phase 3

Conditions studied: Respiratory Syncytial Virus Infections

In brief

The purpose of this study is to test the safety and effectiveness of ribavirin, administered as an aerosol, in preventing progression of upper respiratory tract RSV infection to RSV pneumonia in bone marrow and peripheral blood transplant recipients.

Key facts

Study ID

NCT00031473

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

90

Starts

1997-11-01

Expected to finish

2003-03-01

Last updated by the study team

2010-08-27

Who can join

Age: 5 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 2 years of age or older.
• Are not pregnant or breast-feeding and agree to use a reliable birth control method for the duration of the study.
• Are a blood or bone marrow transplant recipient.
• Have evidence of upper respiratory tract infection.
• Have nasopharyngeal-throat samples positive for RSV.

You may not qualify if…

• Are known to be HIV positive.
• Have pneumonia.
• Require a ventilator to breathe.
• Are pregnant.
• Are breast-feeding and are unwilling to stop breast-feeding.
• Are receiving treatment with certain other drugs for RSV.

Where it is running

• University of Alabama at Birmingham (CASG) — Birmingham, Alabama, United States
• City of Hope National Medical Center — Duarte, California, United States
• University of California, San Francisco — San Francisco, California, United States
• University of Florida — Gainesville, Florida, United States
• University of Chicago — Chicago, Illinois, United States
• J. Whitcomb Riley Hosp for Chldrn - Indianapolis — Indianapolis, Indiana, United States
• University of Maryland — Baltimore, Maryland, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• St. Luke's Hospital (Kansas City, MO) — Kansas City, Missouri, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• SUNY Upstate Medical University — Syracuse, New York, United States

Full record on ClinicalTrials.gov

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