Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome
Completed
Conditions studied: Tourette Syndrome
In brief
This study will use magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of the brain to try to gain a better understanding of the disease process in Tourette s syndrome, a neuropsychiatric disorder characterized by motor and vocal tics. Tourette s syndrome is also associated with behavioral and emotional disturbances, including symptoms of attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). MRI and MRS show chemical substances in the brain. Findings in normal volunteers will be compared with those of patients. Healthy volunteers and patients with Tourette s syndrome 14 years of age and older may be eligible for this study. Volunteers will be screened with a medical history and physical and neurological examinations. Patients will be screened through NINDS protocol 93-N-0202. Participants will undergo MRI and MRS. MRI uses a strong magnetic field and radio waves to visualize brain anatomy and chemistry. For this study, the subject lies on a stretcher, which is moved into a strong magnetic field (the MRI scanner). Earplugs are worn to muffle loud thumping noises caused by the electrical switching of the radio frequency circuits. During the study, the subject lies still during each scan, for 1 to 8 minutes at a time. Total scanning time varies from 20 minutes to 2 hours, with most examinations lasting between 45 and 90 minutes. The subject can speak through an intercom with the staff member performing the study at all times during the procedure. Up to 5 studies may be performed.
Key facts
- Study ID
- NCT00030953
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 100
- Starts
- 2002-02-11
- Expected to finish
- 2015-02-03
- Last updated by the study team
- 2019-12-17
Who can join
Age: 14 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Subjects younger than 14 years old.
- Patients with MRI findings consistent with brain tumors, strokes, trauma or arteriovenous malformations (AVMs).
- Patients with progressive neurological disorders other than Tourette's syndrome.
- Patients with a history of significant medical disorders, or who require chronic treatment with other drugs which cannot be stopped.
- Subjects with implanted devices such as pacemakers, medication pumps or defibrillators, metal in the cranium except mouth, intracardiac lines, history of shrapnel injury or any other condition/device that may be contraindicated or prevent the acquisition of the MRI.
- Patients with cancer.
- Patients not capable of giving an informed consent.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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