Extract of Ginkgo Biloba (EGB 761) and Vascular Function
Completed · Phase 1/Phase 2
Conditions studied: Intermittent Claudication, Peripheral Vascular Disease
In brief
This study will determine if a highly standardized herbal extract of the leaves of the Ginkgo Biloba tree will benefit patients who have pain on walking due to narrowing of the arteries of the legs.
Key facts
- Study ID
- NCT00029991
- Run by
- National Center for Complementary and Integrative Health (NCCIH)
- People needed
- 100
- Starts
- 2000-09-01
- Expected to finish
- 2005-07-01
- Last updated by the study team
- 2006-08-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Males and non-pregnant females.
- Intermittent claudication or rest pain due to peripheral arterial disease, in a steady clinical state for at least three months according to physician's opinion. The peripheral arterial disease must be confirmed by Doppler ankle brachial index (ABI).
- Wash-out of disallowed medications of at least four weeks prior to screening.
- Patient understands all elements of informed consent and has agreed to it in writing prior to enrollment.
You may not qualify if…
- Peripheral arterial disease of non-atherosclerotic nature.
- Inability to walk at least 50 feet on a standardized treadmill.
- Any type of major surgery during the last three months and, in particular, aortic or lower extremity arterial surgery, angioplasty, or lumbar sympathectomy within 3 months; leg amputation above the ankle.
- Any disease process, other than PAD, limiting exercise capacity on the treadmill.
- Myocardial infarction in the previous 3 months.
- Current enrollment in another clinical trial and/or ingestion of another investigational product within the past 30 days.
- Diabetes retinopathy, age-related maculopathy, or any other proliferative retinopathy.
- Active malignant disease or history of malignancy.
- Intolerance to sublingual nitroglycerin.
- Uncontrolled hypertension.
- Type I diabetes.
- Use of pentoxifylline, carnitine, arginine or prostacyclin.
- Use of antioxidants other than those in the usual multivitamin mixture.
Where it is running
- Stanford University — Stanford, California, United States
Full record on ClinicalTrials.gov
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