A Study of Patients Who Develop HIV Infection After Enrolling in HIV Vaccine Trials or HIV Vaccine Preparedness Trials

Completed

Conditions studied: HIV Infections

In brief

Despite risk reduction counseling, some individuals in HIV vaccine trials or vaccine preparedness studies may engage in risk behavior that results in HIV infection. The purpose of the HVTN 403 study is to find out more about how persons respond to HIV infection if they have received an experimental HIV-1 vaccine before they became HIV infected. Some people in HVTN 403 received an experimental HIV vaccine as a participant in a clinical trial before getting infected with HIV. Other people in this study were in a vaccine preparedness study when they got infected with HIV. None of these individuals became infected with HIV as result of their participation in an HIV vaccine or vaccine preparedness study. HVTN 403 will compare immune responses between those who previously received an experimental HIV vaccine and those who did not. Information learned from this study may be important in guiding future developments of new HIV vaccines and other treatments for HIV and AIDS.

Key facts

Study ID

NCT00029913

Run by

HIV Vaccine Trials Network

People needed

54

Starts

2002-04-01

Expected to finish

2009-07-01

Last updated by the study team

2010-09-02

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participated in HVTN, AVEG, HIVNET Phase I or Phase II vaccine trials or HIV vaccine preparedness trial HVTN 903 and became HIV infected after study enrollment.
• Are able and willing to provide information so that they may be located.

You may not qualify if…

• Have a medical or mental problem that, in the opinion of the investigator, would interfere with the study.

Where it is running

• Univ of Alabama at Birmingham — Birmingham, Alabama, United States
• Mt Zion Hospital — San Francisco, California, United States
• San Francisco Dept of Hlth / AIDS Office — San Francisco, California, United States
• University of MD - Inst. of Human Virology (IHV) — Baltimore, Maryland, United States
• Jhu-Cir/Dc — Baltimore, Maryland, United States
• Johns Hopkins Univ — Baltimore, Maryland, United States
• Fenway Community Health — Boston, Massachusetts, United States
• Harvard University / Brigham and Women's Hospital — Boston, Massachusetts, United States
• Saint Louis University School of Medicine — St Louis, Missouri, United States
• New York Blood Ctr / Union Square — New York, New York, United States
• Columbia Univ — New York, New York, United States
• Univ of Rochester Med Ctr — Rochester, New York, United States
• Miriam Hosp — Providence, Rhode Island, United States
• Vanderbilt Univ Hosp — Nashville, Tennessee, United States
• Fred Hutchinson Cancer Research Ctr — Seattle, Washington, United States
• Hospital Escola Sao Francisco de Assis (HESFA) — Cidade Nova, Brazil
• Asociacion Civil Selva Amazonica — Iquitos, Loreto, Peru
• Impacta - Asociacion Civil Impacta Salud y Educaci — Lima, Peru
• KOSH District HVTU — Klerksdorp, North West, South Africa
• Perinatal HIV Research Unit, Chris Hani Baragwanat — Bertsham, South Africa
• University of Cape Town. Institute of Infectious Diseases — Mowbray, South Africa

Full record on ClinicalTrials.gov

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