Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients

Completed · Phase 2

Conditions studied: Anemia, Sickle Cell, Pneumonia

In brief

This is a study to determine if oral arginine will increase nitric oxide in sickle cell disease (SCD) patients with acute chest syndrome (ACS). It will also assess the effects of arginine in the body and how the body uses nitric oxide in ACS.

Key facts

Study ID

NCT00029731

Run by

UCSF Benioff Children's Hospital Oakland

People needed

30

Starts

2001-08-01

Expected to finish

2005-07-01

Last updated by the study team

2015-03-25

Who can join

Age: 5 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of sickle cell disease (Hb SS, SC, or Sbeta thalassemia)
• Acute chest syndrome with the following:
• New pulmonary infiltrate on chest radiography involving a full segment of the lung and 1 of the following:
• Fever
• Cough, tachypnea, retractions, rales, or wheezing
• Chest pain

You may not qualify if…

• Inability to take or tolerate oral medications
• Hepatic dysfunction (SGPT greater than 2 times normal)
• Renal dysfunction (creatinine greater than 2 times normal)
• Mental status or neurological changes
• Allergy to arginine
• History of priapism
• Pregnancy

Where it is running

• Children's Hospital Oakland — Oakland, California, United States

Full record on ClinicalTrials.gov

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