Borage Oil and Ginkgo Biloba (EGb 761) in Asthma

Completed · Phase 1/Phase 2

Conditions studied: Asthma

In brief

This study will assess clinical efficacy and/or adverse effects of dietary borage oil (which contains gamma-linolenic acid \[GLA\]) and Ginkgo biloba in patients with mild persistent to moderate asthma.

Key facts

Study ID

NCT00029679

Run by

National Center for Complementary and Integrative Health (NCCIH)

People needed

280

Starts

2000-09-01

Expected to finish

2005-07-01

Last updated by the study team

2006-08-18

Who can join

Age: 16 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Symptoms (cough, wheeze, chest tightness) consistent with the National Asthma Education Program (NAEP) guidelines for mild persistent to moderate asthma

You may not qualify if…

• Severe asthma or mild intermittent asthma by NAEP revised guidelines
• History of vasovagal reactions (nausea, dizziness, flushed/warm) upon having blood drawn
• Pregnancy or lactation
• History of emergency room care in the last 6 months
• History of hospitalization
• Use of prednisone in the past 3 months
• Concurrent pulmonary disease: pulmonary hypertension, cystic fibrosis, sarcoidosis, bronchiectasis, hypersensitivity pneumonitis, restrictive lung disease
• Cigarette smoking within the past 1 year; over 10-pack year history of cigarette smoking in ex-smokers
• Recent (within one month) upper or lower respiratory tract infection
• The following concurrent medical diagnoses: alcoholism, coronary artery disease, diabetes, HIV infection, chronic hepatitis, uncontrolled hypertension, or a psychiatric disorder that is judged to make full participation difficult
• Use of prednisone in the past 3 months; current use of zileuton (leukotriene receptor antagonists are allowed) or theophylline
• Use of dietary supplements (except for standard dose multiple vitamins such as One-a-day or Centrum) including herbal supplements, mega dose of multiple vitamins/antioxidants, magnesium, fish oil, borage oil, evening primrose oil, black currant oil, fungal oil, G. biloba, quercetin, or mega intake of garlic or onion (subjects will be asked to stop such therapies as a requirement of enrollment)
• Ongoing use of homeopathic remedies or acupuncture, acupressure, therapeutic massage (subjects will be asked to stop such therapies as a requirement of enrollment)

Where it is running

• University of California, Davis — Sacramento, California, United States

Full record on ClinicalTrials.gov

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