Monoclonal Antibody Plus Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes
Completed · Phase 1
Conditions studied: Leukemia, Myelodysplastic Syndromes
In brief
RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as gemtuzumab ozogamicin can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Combining monoclonal antibody therapy with combination chemotherapy may kill more cancer cells. PURPOSE: Phase I trial to study the effectiveness of combining gemtuzumab ozogamicin with combination chemotherapy in treating children who have relapsed or refractory acute myeloid leukemia or myelodysplastic syndrome.
Key facts
- Study ID
- NCT00028899
- Run by
- Children's Oncology Group
- People needed
- 47
- Starts
- 2002-07-01
- Expected to finish
- 2012-03-01
- Last updated by the study team
- 2014-02-20
Who can join
Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Phoenix Children's Hospital — Phoenix, Arizona, United States
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
- Children's Hospital Los Angeles — Los Angeles, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- Children's Hospital and Health Center - San Diego — San Diego, California, United States
- Stanford Cancer Center at Stanford University Medical Center — Stanford, California, United States
- Children's Hospital Cancer Center — Denver, Colorado, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- University of Florida Shands Cancer Center — Gainesville, Florida, United States
- Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
- All Children's Hospital — St. Petersburg, Florida, United States
- St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States
- Kaplan Cancer Center at St. Mary's Medical Center — West Palm Beach, Florida, United States
- Emory University Hospital - Atlanta — Atlanta, Georgia, United States
- Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- Indiana University Cancer Center — Indianapolis, Indiana, United States
- St. Vincent Indianapolis Hospital — Indianapolis, Indiana, United States
- Markey Cancer Center at University of Kentucky Chandler Medical Center — Lexington, Kentucky, United States
- CancerCare of Maine at Eastern Maine Medial Center — Bangor, Maine, United States
- Alvin and Lois Lapidus Cancer Institute at Sinai Hospital — Baltimore, Maryland, United States
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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