Hormone Therapy Compared With Combination Chemotherapy in Treating Patients With Prostate Cancer

Completed · Phase 3

Conditions studied: Prostate Cancer

In brief

RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as ketoconazole may stop the production of androgens. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether hormone therapy is more effective than combination chemotherapy in treating prostate cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy with that of combination chemotherapy in treating patients who have prostate cancer that has been previously treated with androgen suppression.

Key facts

Study ID

NCT00027859

Run by

Eastern Cooperative Oncology Group

Starts

2003-10-08

Last updated by the study team

2023-06-15

Who can join

Age: 18 and older, up to 120. Sex: male. Healthy volunteers: not accepted.

Where it is running

• CCOP - Mayo Clinic Scottsdale Oncology Program — Scottsdale, Arizona, United States
• Veterans Affairs Medical Center - Tucson — Tucson, Arizona, United States
• Veterans Affairs Medical Center - Little Rock — Little Rock, Arkansas, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
• Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center — Los Angeles, California, United States
• Veterans Affairs Outpatient Clinic - Martinez — Martinez, California, United States
• Naval Medical Center - San Diego — San Diego, California, United States
• UCSF Comprehensive Cancer Center — San Francisco, California, United States
• Medical Center of Aurora - South Campus — Aurora, Colorado, United States
• Boulder Community Hospital — Boulder, Colorado, United States
• Penrose Cancer Center at Penrose Hospital — Colorado Springs, Colorado, United States
• Porter Adventist Hospital — Denver, Colorado, United States
• St. Joseph Hospital — Denver, Colorado, United States
• Presbyterian - St. Luke's Medical Center — Denver, Colorado, United States
• Rocky Mountain Cancer Centers - Denver Rose — Denver, Colorado, United States
• Veterans Affairs Medical Center - Denver — Denver, Colorado, United States
• CCOP - Colorado Cancer Research Program, Incorporated — Denver, Colorado, United States
• Swedish Medical Center — Englewood, Colorado, United States
• Sky Ridge Medical Center — Lone Tree, Colorado, United States
• Hope Cancer Care Center at Longmont United Hospital — Longmont, Colorado, United States
• St. Mary-Corwin Regional Medical Center — Pueblo, Colorado, United States
• Rocky Mountain Cancer Centers - Thornton — Thornton, Colorado, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• Comprehensive Cancer Institute — Huntsville, Alabama, United States

Full record on ClinicalTrials.gov

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