Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma

Completed · Phase 2

Conditions studied: Brain Tumor, Central Nervous System Tumor

In brief

RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy before surgery may shrink the tumor so that it can be removed during surgery. PURPOSE: Phase II trial to determine the effectiveness of specialized radiation therapy either alone or after chemotherapy and second surgery in treating children who have undergone surgery for localized ependymoma.

Key facts

Study ID

NCT00027846

Run by

Children's Oncology Group

People needed

378

Starts

2003-08-01

Expected to finish

2016-03-31

Last updated by the study team

2019-08-07

Who can join

Age: 1 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Phoenix Children's Hospital — Phoenix, Arizona, United States
• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Southern California Permanente Medical Group — Downey, California, United States
• Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
• Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
• Childrens Hospital Los Angeles — Los Angeles, California, United States
• Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center — Los Angeles, California, United States
• Children's Hospital Central California — Madera, California, United States
• Children's Hospital & Research Center Oakland — Oakland, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Sutter Cancer Center — Sacramento, California, United States
• University of California Davis Cancer Center — Sacramento, California, United States
• Kaiser Permanente Medical Center - Oakland — Sacramento, California, United States
• Children's Hospital and Health Center - San Diego — San Diego, California, United States
• UCSF Comprehensive Cancer Center — San Francisco, California, United States
• Stanford Comprehensive Cancer Center - Stanford — Stanford, California, United States
• Children's Hospital Cancer Center — Denver, Colorado, United States
• Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center — Farmington, Connecticut, United States
• Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
• University of Florida Shands Cancer Center — Gainesville, Florida, United States
• Nemours Children's Clinic — Jacksonville, Florida, United States
• Miami Children's Hospital — Miami, Florida, United States
• Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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