Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal Cancer

Status unconfirmed · Phase 2

Conditions studied: Colorectal Cancer

In brief

RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Tetanus toxoid may make tumor cells more sensitive to chemotherapy and vaccine therapy. PURPOSE: Randomized phase II trial to study the effectiveness of chemotherapy and vaccine therapy with or without tetanus toxoid compared with chemotherapy alone in treating patients who have metastatic colorectal cancer.

Key facts

Study ID

NCT00027833

Run by

Herbert Irving Comprehensive Cancer Center

Starts

2001-12-01

Last updated by the study team

2014-01-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• Lombardi Cancer Center — Washington D.C., District of Columbia, United States
• H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
• Robert H. Lurie Comprehensive Cancer Center, Northwestern University — Chicago, Illinois, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• Herbert Irving Comprehensive Cancer Center — New York, New York, United States
• Earle A. Chiles Research Institute at Providence Portland Medical Center — Portland, Oregon, United States
• Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
• Scranton Hematology-Oncology — Scranton, Pennsylvania, United States
• Ottawa Regional Cancer Centre — Ottawa, Ontario, Canada
• Princess Margaret Hospital — Toronto, Ontario, Canada
• McGill University — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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