Combination Chemotherapy and Total-Body Irradiation Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia

Completed · Phase 1/Phase 2

Conditions studied: Leukemia

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy and radiation therapy. Sometimes the transplanted cells are rejected by the body's normal tissues. Mycophenolate mofetil and donor white blood cells may prevent this from happening. PURPOSE: Phase I/II trial to determine the effectiveness of combination chemotherapy and total-body irradiation followed by peripheral stem cell transplantation in treating patients who have acute lymphoblastic leukemia.

Key facts

Study ID

NCT00027547

Run by

Fred Hutchinson Cancer Center

Starts

2001-07-01

Expected to finish

2004-07-01

Last updated by the study team

2011-11-30

Who can join

Age: any, up to 75. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Cancer Institute at Oregon Health and Science University — Portland, Oregon, United States
• Fred Hutchinson Cancer Research Center — Seattle, Washington, United States
• Universitaet Leipzig — Leipzig, Germany

Full record on ClinicalTrials.gov

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