Effects of St. John's Wort on the Effectiveness of Oral Contraceptives

Completed · Not applicable

Conditions studied: Contraception

In brief

The purpose of this study is to evaluate the effects of a common herbal remedy, St. John's Wort, on the effectiveness of birth control pills. St. John's Wort has recently been shown to increase metabolism of some drugs. If it could increase metabolism of oral contraceptives as well, it may increase the risk of contraceptive failure and unintended pregnancy. Study participants will be evaluated for risk of ovulation on oral contraceptives before and during simultaneous therapy with St. John's Wort.

Key facts

Study ID

NCT00026013

Run by

National Center for Complementary and Integrative Health (NCCIH)

People needed

25

Starts

2002-01-01

Expected to finish

2004-01-01

Last updated by the study team

2006-08-18

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women taking or willing to take low dose oral contraceptives for 5 months
• No contraindications to hormonal contraception

Where it is running

• Columbia University Department of Obstetrics & Gynecology — New York, New York, United States

Full record on ClinicalTrials.gov

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