EEG and EMG Analysis of Ideomotor Apraxia

Completed

Conditions studied: Ideomotor Apraxia

In brief

This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease. It will use electroencephalography (EEG) and electromyography (EMG) to compare brain function in normal subjects and in patients with-a disorder affecting patients with stroke and other brain lesions. These patients have problems with timing, sequence and spatial organization of certain types of movements. EEG measures the electrical activity of the brain. The activity is recorded using wire electrodes attached to the scalp or mounted on a Lycra cap placed on the head. EMG measures electrical activity from muscles. It uses wire electrodes placed on the skin over the muscles. Adult healthy normal volunteers and patients with ideomotor apraxia with a single left brain lesion may be eligible for this study. Study participants will be asked to make certain movements with their arms or hands, such as waving and using scissors. Brain and muscle activity will be measured during these tasks with EEG and EMG recordings. Patients may be asked to repeat these tests over time as their condition changes (such as during recovery from a stroke) to gain information about the recovery process.

Key facts

Study ID

NCT00024999

Run by

National Institute of Neurological Disorders and Stroke (NINDS)

People needed

60

Starts

2001-10-01

Expected to finish

2005-09-01

Last updated by the study team

2008-03-04

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Normal subjects.
• Patients diagnosed with Ideomotor apraxia with a single left hemisphere lesion.
• Patients with Ideomotor apraxia with corticobasal ganglionic degeneration.

You may not qualify if…

• Normal subjects: abnormal neurologic examination or history of neurologic disorders.
• Ideomotor apraxic patients: a second neurologic disorder including more than one brain lesion or the inability to cooperate fully.
• Normal and Ideomotor apraxic patients: cognitively impaired subjects will not be accrued (for the purposes of this study, patients that can provide full informed consent for the study are not considered cognitively impaired).
• For MRI studies, patients with metallic implants to remove potential risks from this procedure.
• For MRI purposes, women who are pregnant are excluded from this part of the protocol. Therefore, all women of childbearing potential will have a pregnancy test performed, which must be negative, before proceeding.

Where it is running

• National Institute of Neurological Disorders and Stroke (NINDS) — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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