Triacetyluridine and Fluorouracil Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced, or Metastatic Pancreatic Cancer

Completed · Phase 3

Conditions studied: Drug/Agent Toxicity by Tissue/Organ, Pancreatic Cancer

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving the drugs in different combinations may kill more tumor cells. Chemoprotective drugs such as triacetyluridine may protect normal cells from the side effects of chemotherapy. It is not yet known which chemotherapy regimen is more effective in treating pancreatic cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of fluorouracil plus triacetyluridine with that of gemcitabine in treating patients who have locally advanced or metastatic pancreatic cancer that cannot be treated with surgery.

Key facts

Study ID

NCT00024427

Run by

Wellstat Therapeutics

People needed

250

Starts

2001-02-01

Last updated by the study team

2012-06-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Brookwood Medical Center — Birmingham, Alabama, United States
• Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States
• Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Scripps Cancer Center at Scripps Clinic — La Jolla, California, United States
• Northwest Oncology and Hematology Associates — Coral Springs, Florida, United States
• Florida Cancer Specialists - World Plaza — Fort Myers, Florida, United States
• Memorial Cancer Institute at Memorial Regional Hospital — Hollywood, Florida, United States
• Florida Oncology Associates - South Side — Jacksonville, Florida, United States
• University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
• Florida Cancer Institute - New Port Richey — New Port Richey, Florida, United States
• St. Joseph's Hospital — Savannah, Georgia, United States
• Cancer Care Center — New Albany, Indiana, United States
• Cancer Center at Greater Baltimore Medical Center — Baltimore, Maryland, United States
• Wellstat Therapeutics — Gaithersburg, Maryland, United States
• CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
• Capitol Comprehensive Cancer Care Clinic — Jefferson City, Missouri, United States
• David C. Pratt Cancer Center at St. John's Mercy — St Louis, Missouri, United States
• University of New Mexico Cancer Research and Treatment Center — Albuquerque, New Mexico, United States
• Queens Medical Associates, PC — Fresh Meadows, New York, United States
• New York Weill Cornell Cancer Center at Cornell University — New York, New York, United States
• Summit Oncology Associates — Akron, Ohio, United States
• Penn State Cancer Institute at Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
• Fox Chase - Temple Cancer Center — Philadelphia, Pennsylvania, United States
• Cancer Centers of the Carolinas - Eastside — Greenville, South Carolina, United States

Full record on ClinicalTrials.gov

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