SU6668 in Treating Patients With Advanced Solid Tumors
Completed · Phase 1
Conditions studied: Unspecified Adult Solid Tumor, Protocol Specific
In brief
Phase I trial to study the effectiveness of SU6668 in treating patients who have advanced solid tumors. SU6668 may stop the growth of solid tumors by stopping blood flow to the tumor
Key facts
- Study ID
- NCT00024206
- Run by
- National Cancer Institute (NCI)
- People needed
- 12
- Starts
- 2001-07-01
- Last updated by the study team
- 2013-01-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed advanced solid tumor for which no standard therapy exists
- At least 1 measurable tumor lesion (at least 2 cm) not previously irradiated
- No history of brain metastases
- Negative brain CT/MRI required for patients with signs and symptoms suspicious for brain metastases
- Performance status - ECOG 0-1
- WBC greater than 3,000/mm\^3
- Absolute neutrophil count greater than 1,500/mm\^3
- Platelet count greater than 100,000/mm\^3
- Hemoglobin greater than 10 g/dL
- No history of bleeding diathesis
- Bilirubin no greater than 1.5 times upper limit of normal (ULN)
- ALT less than 2.5 times ULN
- Creatinine less than 1.5 mg/dL
- Creatinine clearance greater than 60 mL/min
- No concurrent uncontrolled medical or psychiatric disorders
- No severe iodine allergy
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- At least 30 days since prior over-the-counter, anticancer biologic agents (e.g., shark cartilage)
- No concurrent over-the-counter, anticancer biologic agents (e.g., shark cartilage)
- At least 3 weeks since prior cytotoxic or cytostatic agents (6 weeks for nitrosoureas or mitomycin)
- Patients with ECOG performance status 0:
- Any number of prior chemotherapy regimens allowed
- Patients with ECOG performance status 1:
Where it is running
- M D Anderson Cancer Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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