Radiation Therapy Plus Celecoxib, Fluorouracil, and Cisplatin in Patients With Locally Advanced Cervical Cancer
Completed · Phase 1/Phase 2
Conditions studied: Cervical Cancer
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving radiation therapy in different ways and combining it with chemotherapy may kill more tumor cells. Celecoxib may slow the growth of cervical cancer by stopping blood flow to the tumor. PURPOSE: Phase I/II trial to study the effectiveness of radiation therapy plus celecoxib, fluorouracil, and cisplatin in treating patients who have locally advanced cervical cancer.
Key facts
- Study ID
- NCT00023660
- Run by
- Radiation Therapy Oncology Group
- People needed
- 84
- Starts
- 2001-08-01
- Last updated by the study team
- 2013-11-19
Who can join
Age: 18 and older, up to 85. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Mobile Infirmary Medical Center — Mobile, Alabama, United States
- Foundation for Cancer Research and Education — Phoenix, Arizona, United States
- Mills-Peninsula Health Services — Burlingame, California, United States
- Sutter Health Western Division Cancer Research Group — Greenbrae, California, United States
- UCSF Comprehensive Cancer Center — San Francisco, California, United States
- Memorial Hospital Cancer Center — Colorado Springs, Colorado, United States
- Baptist Hospital of Miami — Miami, Florida, United States
- Regional Radiation Oncology Center at Rome — Rome, Georgia, United States
- Methodist Medical Center of Illinois — Peoria, Illinois, United States
- Ball Memorial Hospital Cancer Center — Muncie, Indiana, United States
- West Michigan Cancer Center — Kalamazoo, Michigan, United States
- CCOP - Kansas City — Kansas City, Missouri, United States
- Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha — Omaha, Nebraska, United States
- CCOP - Southern Nevada Cancer Research Foundation — Las Vegas, Nevada, United States
- Monmouth Medical Center — Long Branch, New Jersey, United States
- South Jersey Regional Cancer Center — Millville, New Jersey, United States
- Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital — Mount Holly, New Jersey, United States
- Newark Beth Israel Medical Center — Newark, New Jersey, United States
- Community Medical Center — Toms River, New Jersey, United States
- State University of New York Health Science Center at Brooklyn — Brooklyn, New York, United States
- New York Methodist Hospital — Brooklyn, New York, United States
- Comprehensive Cancer Center at Wake Forest University — Winston-Salem, North Carolina, United States
- Akron General Medical Center — Akron, Ohio, United States
- Akron City Hospital - Summa Health System — Akron, Ohio, United States
- Bryn Mawr Hospital — Bryn Mawr, Pennsylvania, United States
Full record on ClinicalTrials.gov
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