TBTC Study 23C: Pharmacokinetics of Intermittent Rifabutin and Isoniazid With Daily Efavirenz
Completed · Phase 2
Conditions studied: HIV Infections, Tuberculosis
In brief
The aim of this trial is to study the efavirenz-rifabutin interaction. Thus, this trial will enroll patients with HIV and tuberculosis co-infections who are receiving a rifabutin-based regimen and who plan to begin an antiretroviral regimen containing efavirenz dosed at 600 mg daily. Enrollment in TB Trials Consortium Study 23 is not a requirement for participation in this study. Primary Objective: To compare the pharmacokinetics of rifabutin at 600 mg twice a week in combination with efavirenz 600 mg daily to the pharmacokinetics of rifabutin 300 mg twice a week without efavirenz.
Key facts
- Study ID
- NCT00023413
- Run by
- Centers for Disease Control and Prevention
- People needed
- 20
- Starts
- 1999-11-01
- Expected to finish
- 2004-02-01
- Last updated by the study team
- 2012-06-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Central Arkansas Veterans Health System — Little Rock, Arkansas, United States
- LA County/USC Medical Center — Los Angeles, California, United States
- University of California, San Francisco — San Francisco, California, United States
- Denver Department of Public Health and Hospitals — Denver, Colorado, United States
- Washington, D.C. VAMC — Washington D.C., District of Columbia, United States
- Chicago VA Medical Center (Lakeside) — Chicago, Illinois, United States
- Hines VA Medical Center — Hines, Illinois, United States
- Johns Hopkins University School of Medicine — Baltimore, Maryland, United States
- Boston Medical Center — Boston, Massachusetts, United States
- New Jersey Medical School — Newark, New Jersey, United States
- New York University School of Medicine — New York, New York, United States
- Columbia University/Presbyterian Medical Center — New York, New York, United States
- Harlem Hospital Center — New York, New York, United States
- Carolinas Medical Center — Charlotte, North Carolina, United States
- Duke University Medical Center — Durham, North Carolina, United States
- Nashville VA Medical Center — Nashville, Tennessee, United States
- University of North Texas Health Science Center — Fort Worth, Texas, United States
- Thomas Street Clinic — Houston, Texas, United States
- Audi L. Murphy VA Hospital — San Antonio, Texas, United States
- Seattle King County Health Department — Seattle, Washington, United States
- University of British Columbia — Vancouver, British Columbia, Canada
- University of Manitoba — Winnipeg, Manitoba, Canada
- Montreal Chest Institute McGill University — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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