Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

Completed · Phase 4

Conditions studied: Depression

In brief

STAR\*D focuses on non-psychotic major depressive disorder in adults who are seen in outpatient settings. The primary purpose of this research study is to determine which treatments work best if the first treatment with medication does not produce an acceptable response. Participants will first receive citalopram, an SSRI medication; if symptoms remain after 8-12 weeks of treatment, up to four other levels of treatment will be offered, including cognitive therapy and other medications. There are no placebo treatments. Some patients may require a combination of two or more treatments to obtain full benefit. Participation could last from 15 to 27 months and involve up to 30 clinic visits. Participants will be interviewed by telephone throughout the study about their symptoms, daily functioning, treatment side effects, use of the health care system, and satisfaction with treatment. There will be a one-year follow up for participants once their depression has been successfully treated

Key facts

Study ID

NCT00021528

Run by

National Institute of Mental Health (NIMH)

People needed

4000

Starts

2001-07-01

Expected to finish

2006-09-01

Last updated by the study team

2009-09-25

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Birmingham VA Medical Center — Birmingham, Alabama, United States
• Tuscaloosa VA Mental Health Clinic - Veterans Only — Tuscaloosa, Alabama, United States
• Tuscaloosa VA Primary Care Center — Tuscaloosa, Alabama, United States
• Psychiatric Centers at San Diego — Chula Vista, California, United States
• Harbor UCLA Family Health Care Center — Harbor City, California, United States
• UCLA General Outpatient Psychiatry Clinic — Los Angeles, California, United States
• UCLA Internal Medicine Clinic — Los Angeles, California, United States
• UCSD Outpatient Psychiatric Services — San Diego, California, United States
• Veterans Affairs Medical Center/FIRM Primary Care Clinic — San Diego, California, United States
• Harbor UCLA Medical Center — Torrance, California, United States
• Northwestern Outpatient Treatment Care Center — Chicago, Illinois, United States
• University of Illinois at Chicago Clinic — Chicago, Illinois, United States
• Evanston Outpatient Clinic — Evanston, Illinois, United States
• COMCARE of Sedgwick County — Wichita, Kansas, United States
• Psychiatric Outpatient Clinic — Wichita, Kansas, United States
• Swampscott Family Doctors — Boston, Massachusetts, United States
• Internal Medicine Associates — Boston, Massachusetts, United States
• MGH/Charlestown Clinic — Charlestown, Massachusetts, United States
• MGH/Salem Professional — Salem, Massachusetts, United States
• General Psychiatric Ambulatory Clinic — Ann Arbor, Michigan, United States
• Briarwood Family Practice Clinic — Ann Arbor, Michigan, United States
• LIJ/Zucker Hillside Adult Ambulatory Care Center — Glen Oaks, New York, United States
• LIJ North Shore Medical Group — Lake Success, New York, United States
• UNC Chapel Hill General Medicine Clinic — Chapel Hill, North Carolina, United States
• UNC Chapel Hill Adult Diagnostic & Treatment Clinic — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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