Chemotherapy and Rituximab With Peripheral Stem Cell Transplantation in Treating Patients With Mantle Cell Lymphoma

Completed · Phase 2

Conditions studied: Lymphoma

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combining chemotherapy and rituximab with peripheral stem cell transplantation in treating patients who have mantle cell lymphoma.

Key facts

Study ID

NCT00020943

Run by

Alliance for Clinical Trials in Oncology

People needed

79

Starts

2001-06-01

Expected to finish

2009-09-01

Last updated by the study team

2016-07-19

Who can join

Age: 18 and older, up to 69. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Veterans Affairs Medical Center - Birmingham — Birmingham, Alabama, United States
• Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
• Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center — Los Angeles, California, United States
• Naval Medical Center - San Diego — San Diego, California, United States
• Veterans Affairs Medical Center - San Diego — San Diego, California, United States
• UCSF Comprehensive Cancer Center — San Francisco, California, United States
• Veterans Affairs Medical Center - San Francisco — San Francisco, California, United States
• Hematology/Oncology Faculty Practice — San Francisco, California, United States
• CCOP - Christiana Care Health Services — Newark, Delaware, United States
• Lombardi Cancer Center at Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• Veterans Affairs Medical Center - Washington, DC — Washington D.C., District of Columbia, United States
• Broward General Medical Center — Fort Lauderdale, Florida, United States
• Memorial Regional Cancer Center at Memorial Regional Hospital — Hollywood, Florida, United States
• CCOP - Mount Sinai Medical Center — Miami Beach, Florida, United States
• Palm Beach Cancer Institute — West Palm Beach, Florida, United States
• Veterans Affairs Medical Center - Chicago (Westside Hospital) — Chicago, Illinois, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• Louis A. Weiss Memorial Hospital — Chicago, Illinois, United States
• CCOP - Illinois Oncology Research Association — Peoria, Illinois, United States
• West Suburban Center for Cancer Care — River Forest, Illinois, United States
• Fort Wayne Medical Oncology and Hematology, Incorporated — Fort Wayne, Indiana, United States
• CCOP - Northern Indiana CR Consortium — South Bend, Indiana, United States
• Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
• Northeast Alabama Regional Medical Center — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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