Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma

Status unconfirmed · Phase 3

Conditions studied: Sarcoma

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy and kill more tumor cells. It is not yet known if combination chemotherapy is more effective with or without radiation therapy and/or surgery in treating Ewing's sarcoma. PURPOSE: This randomized phase III trial is studying different combination chemotherapy regimens to see how well they work when given with or without peripheral stem cell transplantation, radiation therapy, and/or surgery in treating patients with Ewing's sarcoma.

Key facts

Study ID

NCT00020566

Run by

University of Leicester

People needed

1200

Starts

2001-02-01

Last updated by the study team

2014-06-24

Who can join

Age: any, up to 49. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Phoenix Children's Hospital — Phoenix, Arizona, United States (enrolling)
• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States (enrolling)
• City of Hope Comprehensive Cancer Center — Duarte, California, United States (enrolling)
• Childrens Hospital Los Angeles — Los Angeles, California, United States (enrolling)
• Southern California Permanente Medical Group — Los Angeles, California, United States (enrolling)
• Lucile Packard Children's Hospital at Stanford University Medical Center — Palo Alto, California, United States (enrolling)
• Kaiser Permanente Medical Center - Oakland — Sacramento, California, United States (enrolling)
• Rady Children's Hospital - San Diego — San Diego, California, United States (enrolling)
• UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States (enrolling)
• Children's Hospital Colorado Center for Cancer and Blood Disorders — Aurora, Colorado, United States (enrolling)
• Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States (enrolling)
• Children's National Medical Center — Washington D.C., District of Columbia, United States (enrolling)
• Nemours Children's Clinic — Jacksonville, Florida, United States (enrolling)
• University of Miami Sylvester Comprehensive Cancer Center - Miami — Miami, Florida, United States (enrolling)
• Nemours Children's Clinic - Orlando — Orlando, Florida, United States (enrolling)
• Nemours Children's Clinic - Pensacola — Pensacola, Florida, United States (enrolling)
• All Children's Hospital — St. Petersburg, Florida, United States (enrolling)
• St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States (enrolling)
• Kaplan Cancer Center at St. Mary's Medical Center — West Palm Beach, Florida, United States (enrolling)
• AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus — Atlanta, Georgia, United States (enrolling)
• Cancer Research Center of Hawaii — Honolulu, Hawaii, United States (enrolling)
• Mountain States Tumor Institute at St. Luke's Regional Medical Center — Boise, Idaho, United States (enrolling)
• University of Chicago Cancer Research Center — Chicago, Illinois, United States (enrolling)
• Saint Jude Midwest Affiliate — Peoria, Illinois, United States (enrolling)
• UAB Comprehensive Cancer Center — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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