Aldesleukin With or Without Vaccine Therapy in Treating Patients With Locally Advanced or Metastatic Melanoma

Completed · Phase 3

Conditions studied: Recurrent Melanoma, Stage IIIA Skin Melanoma, Stage IIIB Skin Melanoma, Stage IIIC Skin Melanoma, Stage IV Skin Melanoma

In brief

This randomized phase III trial studies aldesleukin with vaccine therapy to see how well it works compared to aldesleukin alone in treating patients with melanoma that has spread from where it started to nearby tissue or lymph nodes or to other places in the body. Aldesleukin may stimulate a person's white blood cells to kill melanoma cells. Vaccines may make the body build an immune response to kill tumor cells. It is not yet known whether combining aldesleukin with vaccine therapy is more effective than aldesleukin alone in treating melanoma.

Key facts

Study ID

NCT00019682

Run by

National Cancer Institute (NCI)

People needed

185

Starts

1999-12-01

Expected to finish

2011-05-01

Last updated by the study team

2017-11-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any patient with measurable metastatic (stage IV or locally advanced stage III) cutaneous melanoma and an expected survival of greater than three months will be considered
• Serum creatinine of 1.6 mg/dl or less
• Total bilirubin 1.6 mg/dl or less
• White blood cell (WBC) 3000/mm\^3 or greater
• Platelet count 90,000 mm\^3 or greater
• Serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) less then three times normal
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• Patients of both genders must be willing to practice effective birth control during this trial
• Pathologic confirmation of cutaneous melanoma; patients may enter the study with a pathologic diagnosis of cutaneous melanoma from any institution; all slides will be reviewed at National Institutes of Health (NIH) (department of Anatomic Pathology) and if the diagnosis is not confirmed, the patient will be excluded from the study
• Tissue type human leukocyte antigen (HLA) A0201

You may not qualify if…

• Patients who have types of melanoma other than cutaneous, i.e. ocular or mucosal
• Patients who are undergoing or have undergone in the past 4 weeks any other form of therapy except surgery for their cancer, including radiation therapy to any site
• Patients who have active systemic infections, coagulation disorders, autoimmune disease or history of other major medical illnesses such as insulin dependent diabetes mellitus, cardiac ischemia, myocardial infarction, cardiac arrhythmias, obstructive or restrictive pulmonary diseases and inflammatory bowel disorders
• Patients who have significant psychiatric disease which in the opinion of the principal investigator would prevent adequate informed consent or render immunotherapy unsafe or contraindicated
• Patients who require steroid therapy or steroid-containing compounds, or have used systemic steroids in the past 4 weeks, or have used topical or inhalational steroids in the past 2 weeks
• Patients who are pregnant
• Patients who are known to be positive for viral hepatitis B or C (hepatitis B surface antigen [HBsAg] or anti hepatitis C virus [HCV]) or human immunodeficiency virus (HIV) (HIV antibody)
• Patients who have any form of primary or secondary immunodeficiency
• Patients who have received previous high dose IL-2 (> 600,000 IU/kg)
• Patients who have received previous gp100 vaccines
• Patients who have an abnormal stress cardiac test (stress thallium, stress multi gated acquisition scan [MUGA], dobutamine echocardiogram or other stress test that will rule out cardiac ischemia)
• Patients who have abnormal pulmonary function tests (forced expiratory volume in one second [FEV1] < 65% or forced vital capacity [FVC] < 65% of predicted)
• Patients who have brain metastasis or history of brain metastasis
• No prior malignancy is allowed except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease free for 5 years

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Mayo Clinic in Arizona — Scottsdale, Arizona, United States
• Kaiser Permanente Medical Center — Riverside, California, United States
• University of Colorado Cancer Center - Anschutz Cancer Pavilion — Aurora, Colorado, United States
• Lakeland Regional Cancer Center — Lakeland, Florida, United States
• Emory University/Winship Cancer Institute — Atlanta, Georgia, United States
• Northwestern University — Chicago, Illinois, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Advocate Lutheran General Hospital. — Park Ridge, Illinois, United States
• IU Health Goshen Center for Cancer Care — Goshen, Indiana, United States
• The James Graham Brown Cancer Center at University of Louisville — Louisville, Kentucky, United States
• National Institutes of Health — Bethesda, Maryland, United States
• Carolinas Medical Center — Charlotte, North Carolina, United States
• The Christ Hospital — Cincinnati, Ohio, United States
• Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
• Saint Luke's University Hospital-Bethlehem Campus — Bethlehem, Pennsylvania, United States
• Penn State Milton S Hershey Medical Center — Hershey, Pennsylvania, United States
• M D Anderson Cancer Center — Houston, Texas, United States
• Aurora Saint Luke's Medical Center — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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