Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate

Completed · Not applicable

Conditions studied: Neurotoxicity, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific

In brief

RATIONALE: Chemoprotective drugs such as carboxypeptidase-G2 may protect normal cells from the toxic effects of chemotherapy. PURPOSE: Clinical trial to study the effectiveness of carboxypeptidase-G2 in treating nervous system toxic effects in patients given an accidental overdose of intrathecal methotrexate.

Key facts

Study ID

NCT00018967

Run by

National Cancer Institute (NCI)

People needed

10

Starts

1993-11-01

Last updated by the study team

2015-04-30

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Phoenix Children's Hospital — Phoenix, Arizona, United States
• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Southern California Permanente Medical Group — Downey, California, United States
• Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
• Children's Hospital Central California — Madera, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Kaiser Permanente Medical Center - Oakland — Sacramento, California, United States
• Children's Hospital and Health Center - San Diego — San Diego, California, United States
• Stanford Comprehensive Cancer Center - Stanford — Stanford, California, United States
• Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
• Nemours Children's Clinic — Jacksonville, Florida, United States
• Miami Children's Hospital — Miami, Florida, United States
• Nemours Children's Clinic - Orlando — Orlando, Florida, United States
• All Children's Hospital — St. Petersburg, Florida, United States
• St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States
• Kaplan Cancer Center at St. Mary's Medical Center — West Palm Beach, Florida, United States
• Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
• Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
• Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• St. Vincent Indianapolis Hospital — Indianapolis, Indiana, United States
• Blank Children's Hospital — Des Moines, Iowa, United States
• University of South Alabama Mitchell Cancer Institute — Mobile, Alabama, United States

Full record on ClinicalTrials.gov

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