Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients

Completed · Phase 4

Conditions studied: Depression, Hypertension

In brief

This study aims to determine if treatment with an SSRI antidepressant medication, paroxetine, is associated with cellular calcium response to serotonin, platelet serotonin receptors, and improvement in mood in depressed patients with or without hypertension. It is hypothesized that platelets of hypertensive patients with depressive symptomatology with be hyper-responsive to serotonin. Additionally, treatment with an SSRI antidepressant is expected to produce a down-regulation of the serotonin receptor with an associated reduction in platelet cytosolic calcium response as well as improved mood.

Key facts

Study ID
NCT00018759
Run by
US Department of Veterans Affairs
Starts
2001-03-01
Expected to finish
2003-10-01
Last updated by the study team
2009-01-21

Who can join

Age: 25 and older, up to 65. Sex: male. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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