Regulation of Sterol Homeostasis

Completed

Conditions studied: Hypertriglyceridemia

In brief

The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol. This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.

Key facts

Study ID

NCT00018720

Run by

US Department of Veterans Affairs

Starts

1996-04-01

Expected to finish

2000-12-01

Last updated by the study team

2009-01-21

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

Where it is running

• VA Medical Center — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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