Cholestanol in Humans

Withdrawn before enrolling · Not applicable

Conditions studied: Cerebrotendinous Xanthomatosis

In brief

The treatment of cerebrotendinous xanthomatosis an in born error of bile acid synthesis with chenodeoxycholic acid. Patients with this disease over produce cholestanol and bile acid precursors because of the block in synthesis. Replacement with chenodeoxycholic acid shut down abnormal pathway and reduces elevated level of cholestanol and improves the clinical syndrome.

Key facts

Study ID

NCT00018694

Run by

US Department of Veterans Affairs

People needed

0

Starts

1999-10-01

Expected to finish

2009-12-01

Last updated by the study team

2013-10-14

Who can join

Age: 5 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with clinical and biochemical findings of cerebrotendinous xanthomatosis. Elevated levels of serum cholestanol and bile acid precursors.

Where it is running

• VA New Jersey Health Care System, East Orange — East Orange, New Jersey, United States

Full record on ClinicalTrials.gov

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