S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma
Completed · Phase 3
Conditions studied: Malignant Neoplasms of Eye, Brain and Other Parts of Central Nervous System
In brief
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. O6-benzylguanine may help carmustine kill more tumor cells by making tumor cells more sensitive to the drug. It is not yet known whether radiation therapy and carmustine are more effective with or without O6-benzylguanine. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy plus carmustine with or without O6-benzylguanine in treating patients who have newly diagnosed glioblastoma multiforme or gliosarcoma.
Key facts
- Study ID
- NCT00017147
- Run by
- SWOG Cancer Research Network
- People needed
- 183
- Starts
- 2001-09-01
- Expected to finish
- 2012-11-01
- Last updated by the study team
- 2013-01-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Banner Good Samaritan Medical Center — Phoenix, Arizona, United States
- CCOP - Western Regional, Arizona — Phoenix, Arizona, United States
- St. Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
- Banner Thunderbird Medical Center — Phoenix, Arizona, United States
- North Bay Cancer Center — Fairfield, California, United States
- Memorial Hospital Cancer Center — Colorado Springs, Colorado, United States
- St. Anthony Central Hospital — Denver, Colorado, United States
- University of Colorado Cancer Center at University of Colorado Health Sciences Center — Denver, Colorado, United States
- North Colorado Medical Center — Greeley, Colorado, United States
- McKee Medical Center — Loveland, Colorado, United States
- St. Anthony North Hospital — Westminster, Colorado, United States
- Exempla Lutheran Medical Center — Wheat Ridge, Colorado, United States
- West Florida Cancer Institute at West Florida Hospital - Pensacola — Pensacola, Florida, United States
- Piedmont Hospital — Atlanta, Georgia, United States
- CCOP - Atlanta Regional — Atlanta, Georgia, United States
- Northside Hospital Cancer Center — Atlanta, Georgia, United States
- Saint Joseph's Hospital of Atlanta — Atlanta, Georgia, United States
- WellStar Cobb Hospital — Austell, Georgia, United States
- Charles B. Eberhart Cancer Center at DeKalb Medical Center — Decatur, Georgia, United States
- Northeast Georgia Medical Center — Gainesville, Georgia, United States
- Gwinnett Medical Center — Lawrenceville, Georgia, United States
- Kennestone Cancer Center at Wellstar Kennestone Hospital — Marietta, Georgia, United States
- Southern Regional Medical Center — Riverdale, Georgia, United States
- Hematology Oncology Associates of Eastern Idaho — Idaho Falls, Idaho, United States
- Alaska Regional Hospital Cancer Center — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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