Combination Chemotherapy Compared With Hormone Therapy in Treating Patients With Recurrent, Stage III, or Stage IV Endometrial Cancer

Stopped early · Phase 3

Conditions studied: Endometrial Cancer

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Estrogen can stimulate the growth of tumor cells. Hormone therapy using tamoxifen and megestrol may fight endometrial cancer by blocking the absorption of estrogen. It is not yet known whether chemotherapy is more effective than hormone therapy in treating endometrial cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with that of hormone therapy in treating patients who have recurrent, stage III, or stage IV endometrial cancer.

Key facts

Study ID

NCT00016341

Run by

Gynecologic Oncology Group

Starts

2001-05-01

Last updated by the study team

2013-04-11

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

Where it is running

• University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Community Hospital of Los Gatos — Los Gatos, California, United States
• Chao Family Comprehensive Cancer Center — Orange, California, United States
• University of Colorado Cancer Center — Denver, Colorado, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
• Rush-Presbyterian-St. Luke's Medical Center — Chicago, Illinois, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• Holden Comprehensive Cancer Center at The University of Iowa — Iowa City, Iowa, United States
• Albert B. Chandler Medical Center, University of Kentucky — Lexington, Kentucky, United States
• Tufts University School of Medicine — Boston, Massachusetts, United States
• University of Massachusetts Memorial Medical Center — Worcester, Massachusetts, United States
• Barbara Ann Karmanos Cancer Institute — Detroit, Michigan, United States
• University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
• Mayo Clinic Cancer Center — Rochester, Minnesota, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Ellis Fischel Cancer Center - Columbia — Columbia, Missouri, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Cooper Hospital/University Medical Center — Camden, New Jersey, United States
• Cancer Center of Albany Medical Center — Albany, New York, United States
• State University of New York Health Science Center at Brooklyn — Brooklyn, New York, United States
• Roswell Park Cancer Institute — Buffalo, New York, United States
• Schneider Children's Hospital at North Shore — Manhasset, New York, United States

Full record on ClinicalTrials.gov

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