CATIE-Alzheimer's Disease Trial

Completed · Not applicable

Conditions studied: Alzheimer's Disease

In brief

The CATIE Alzheimer's Disease Trial is part of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Project. The study is for people with Alzheimer's disease who are having trouble with their thinking or behavior. In particular, this study is trying to find out the best treatment for people who have hallucinations (seeing or hearing things that aren't there), delusions (false beliefs), or agitation. The design of the trial helps to increase the chance that participants in the study receive a medication that helps them. The study uses three medications known as atypical antipsychotics (olanzapine, quetiapine, risperidone), which are the newest medications that are currently available for treating these problems. Participants may also receive an antidepressant (citalopram). The trial lasts for 36 weeks. Participants are given a thorough evaluation at no cost to ensure that this study is appropriate. In addition, the caregiver, family member, or friend who comes with the participant will be offered an educational program about Alzheimer's disease.

Key facts

Study ID

NCT00015548

Run by

National Institute of Mental Health (NIMH)

People needed

450

Starts

2001-03-01

Expected to finish

2004-10-01

Last updated by the study team

2015-06-17

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Dementia of the Alzheimer's Type
• Ambulatory, Outpatients who have an informant living/visiting at least 8 hours/week over 3-4 days.
• Presence of delusions, hallucinations, agitation impacting functioning and requiring medication treatment
• Agitation or psychotic symptoms began after signs or symptoms of dementia
• Exclusion (prospective participants must not:)
• Be benefiting from psychotropic medication, antidepressants or anticonvulsants
• Be diagnosed with schizophrenia, schizoaffective disorder, delusional disorder or mood disorder with psychotic features.
• Have severe or unstable medical illness requiring active treatment
• Have hypersensitivity or intolerance of any of the study medications

Where it is running

• Tuscaloosa VA Medical Center — Tuscaloosa, Alabama, United States
• University of California, Irvine Medical Center — Irvine, California, United States
• University of Southern California Dept of Psychiatry& Behavioral Sciences — Los Angeles, California, United States
• University of California, Los Angeles, VA Medical Center — Los Angeles, California, United States
• University of California-San Diego, VA Medical Center — San Diego, California, United States
• Stanford University School of Medicine — Stanford, California, United States
• Yale University School of Medicine — New Haven, Connecticut, United States
• Mental Health Advocates, Inc. — Boca Raton, Florida, United States
• Berma Research Group — Hialeah, Florida, United States
• University of South Florida Suncoast Gerontology Center — Tampa, Florida, United States
• Palm Beach Neurology/Premiere Research Institute — West Palm Beach, Florida, United States
• Emory University - Wesley Woods Health Center — Atlanta, Georgia, United States
• University of Hawaii — Honolulu, Hawaii, United States
• Northwestern University Medical School — Chicago, Illinois, United States
• Southern Illinois School of Medicine — Springfield, Illinois, United States
• University of Iowa College of Medicine — Iowa City, Iowa, United States
• Louisiana State University Health Sciences Center — Shreveport, Louisiana, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Millennium Psychiatric Associates — St Louis, Missouri, United States
• University of Medicine and Dentistry of New Jersey — Piscataway, New Jersey, United States
• University of Medicine and Dentistry of New Jersey-Stratford — Stratford, New Jersey, United States
• Mount Sinai School of Medicine — New York, New York, United States
• Columbia University — New York, New York, United States
• Global Research and Consulting — Olean, New York, United States
• Monroe Community Hospital — Rochester, New York, United States

Full record on ClinicalTrials.gov

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