Dichloroacetate Kinetics, Metabolism and Toxicology
Completed
Conditions studied: Lactic Acidosis
In brief
Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.
Key facts
- Study ID
- NCT00015015
- Run by
- National Institute of Environmental Health Sciences (NIEHS)
- People needed
- 100
- Starts
- 1994-12-01
- Expected to finish
- 2002-10-01
- Last updated by the study team
- 2006-09-04
Who can join
Age: 0 and older, up to 65. Sex: any. Healthy volunteers: accepted.
Where it is running
- Univ. of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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