A Study of Immune System Activity in Healthy Adults

Completed

Conditions studied: HIV Infections, HIV Seronegativity

In brief

The purpose of this study is to compare immune system activity in young people and older people who do not have HIV. This information will be compared to that of HIV patients in another study. Aging affects immune system activity. This study will look at some of the factors involved. HIV also affects immune system activity. The results from this study, using healthy volunteers, will be compared to those in another study of HIV-infected patients. This may provide information on immune system activity in aging and HIV.

Key facts

Study ID

NCT00014053

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

48

Last updated by the study team

2008-07-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Volunteers may be eligible for this study if they:
• Are willing to undergo HIV testing.
• Have a negative urine or serum pregnancy test within 30 days prior to study entry (for women volunteers).
• Are between the ages of 18 and 30 or are 45 or older.

You may not qualify if…

• Volunteers will not be eligible for this study if they:
• Have HIV infection.
• Have a serious infection or other serious medical illness that requires treatment and/or hospitalization within 90 days before study entry.
• Have had cancer.
• Have received any of the following within 6 months of study entry: systemic corticosteroids; chemotherapy or radiation; erythropoietin, granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), or growth hormone; drugs that affect the immune system including thalidomide, interleukins, interferons, or other cytokines; anabolic steroids at high levels; or any experimental agent, unless allowed otherwise by the researchers.
• Are immune to hepatitis A.
• Have received tetanus toxoid within 5 years prior to study entry or have a history of severe reaction to tetanus vaccine at any time in the past.
• Are pregnant or breast-feeding.

Where it is running

• Univ of California San Francisco — San Francisco, California, United States
• Univ of Colorado Health Sciences Ctr — Denver, Colorado, United States
• Univ of Hawaii — Honolulu, Hawaii, United States
• Northwestern Univ Med School — Chicago, Illinois, United States
• Rush Presbyterian - Saint Luke's Med Ctr — Chicago, Illinois, United States
• Washington Univ School of Medicine — St Louis, Missouri, United States
• Case Western Reserve Univ — Cleveland, Ohio, United States
• Univ of Texas Galveston — Galveston, Texas, United States
• Univ of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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