Ozone and Rhinovirus-Induced Disease in Asthmatics
Completed
Conditions studied: Asthma
In brief
In the U.S., morbidity associated with human rhinovirus (RV) infection represents a major health problem. In asthmatics, up to 80% of asthma exacerbations are associated with upper respiratory infections. Despite evidence that environmental oxidant pollutants, such as ozone, may increase the severity of viral disease, the mechanisms underlying such an effect have not been identified. This study will test the hypothesis that exposure of allergic asthmatic subjects to ambient levels of ozone directly enhances viral disease by increasing infectivity and intensifying virus-induced inflammation.
Key facts
- Study ID
- NCT00013715
- Run by
- National Institute of Environmental Health Sciences (NIEHS)
- People needed
- 60
- Starts
- 1999-09-01
- Expected to finish
- 2003-08-01
- Last updated by the study team
- 2008-08-11
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
Where it is running
- The Johns Hopkins School of Hygiene and Public Health — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.