Immune Therapies and Anti-HIV Therapy Withdrawal in Controlling Viral Load

Completed · Phase 2

Conditions studied: HIV Infections

In brief

The purpose of this study is to determine if HIV-specific canarypox vaccine and/or interleukin-2 (IL-2) will control viral load (amount of HIV in the blood) after HIV treatment is withdrawn for a certain time period.

Key facts

Study ID

NCT00013663

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

92

Expected to finish

2006-06-01

Last updated by the study team

2012-11-02

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients may be eligible for this study if they:
• Are HIV-positive.
• Are more than 18 years old.
• Have been receiving their current HAART (2 or more anti-HIV drugs in combination) for more than 6 consecutive months.
• Have a CD4 count of 200 cells/microL or more within the 12 months prior to entering the study and 400 cells/microL or more on 2 occasions at least 2 weeks apart within 30 days of entry.
• Have never had a viral load higher than 2 million molecules/ml and have had the viral load controlled with HAART to less than 50 molecules/ml on 2 occasions at least 2 weeks apart within 30 days of entry.
• Have not had virologic failure on the current HAART regimen.
• Have a negative urine pregnancy test within 14 days of entering the study.

You may not qualify if…

• Patients will not be eligible for this study if they:
• Have a current AIDS-defining illness.
• Have had failure of the current HAART regimen (viral load higher than 10,000 molecules/ml).
• Have a history of using agents affecting the immune system.
• Have active uncontrolled heart disease.
• Have had IL-2 therapy within 4 weeks of entering the study.
• Have received other treatment that affects the immune system within 4 weeks of entry.
• Have a history of a cancer requiring chemotherapy.
• Have untreated thyroid disease, within 4 weeks of entering the study.
• Have uncontrolled allergic disorders or autoimmune diseases, including asthma, inflammatory bowel disease, and psoriasis.
• Abuse substances that may interfere with the ability to follow study requirements.
• Are allergic to eggs.
• Have hepatitis B or hepatitis C.
• Are pregnant or breast-feeding.
• Work in close contact with canaries, such as a job at breeding farms or bird shops.

Where it is running

• New York Hosp - Cornell Med Ctr — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.