A Prospective Study of Endothelial Dysfunction and Diabetic Foot Ulcer Risk

Completed

Conditions studied: Diabetic Foot Ulcers

In brief

This project will identify risk factors for diabetic foot ulcer by studying the relationship between endothelial dysfunction and foot ulcer risk. A fundamental defect in type 1 and 2 diabetic subjects is impaired vasodilatory reserve which is reflected in the dysfunction of endothelium-dependent vasodilation. Findings thus far point to an important role of the microvasculature in the development of diabetic foot ulcer and amputation. In this study a a well-characterized cohort of 750 diabetic veterans without foot ulcer will be followed over 3-years.

Key facts

Study ID
NCT00013286
Run by
US Department of Veterans Affairs
People needed
750
Starts
1999-10-01
Expected to finish
2002-09-01
Last updated by the study team
2009-01-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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