Effect of Activity on Sleep of Cognitively-Impaired Veterans

Completed · Not applicable

Conditions studied: Alzheimer's Disease, Sleep Disorders

In brief

Sleep-activity rhythm disturbance is a prevalent, disabling symptom in cognitively-impaired (CI) elders. Their nocturnal sleep is light and inefficient with frequent awakenings. Multiple short daytime napping episodes interfere with daytime activity and functioning. Daytime disruptive behaviors, such as pacing, hitting, and cursing are related significantly to sleep-activity rhythm disturbance. Medical treatment for sleep and behavior disturbances with benzodiazepines or antipsychotic medications has proven minimally effective and has serious side effects such as impairments in cognition, memory, coordination, and balance, tolerance and severe rebound insomnia, and tardive dyskinesia.

Key facts

Study ID

NCT00013182

Run by

US Department of Veterans Affairs

People needed

90

Expected to finish

2001-06-01

Last updated by the study team

2015-04-07

Who can join

Age: 55 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Participants must have been a resident in the nursing home for at least two weeks, must be at least 55 years old, have a diagnosis of dementia, a Mini-Mental State Examination Score of <24, sleep less than 85% of the night, and nap at least 30 minutes during the day.

Where it is running

• Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR — No. Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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