Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis

Completed · Phase 2

Conditions studied: Meningitis, Cryptococcal, HIV Infections

In brief

The purpose of this study is to examine the antifungal activity of recombinant interferon-gamma 1b (rIFN-gamma 1b) given with standard antifungal therapy.

Key facts

Study ID

NCT00012467

Run by

InterMune

People needed

60

Starts

2000-01-01

Expected to finish

2001-07-01

Last updated by the study team

2009-06-03

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients may be eligible for Stage 1 if they:
• Are at least 13 years old.
• Have consent of a parent, family member, or guardian if less than 18 years of age.
• Have cryptococcal meningitis for the first time or have had a relapse.
• Are not on any medications that cannot be taken with fluconazole or itraconazole, if the patient has trouble taking fluconazole.
• Patients may be eligible for Stage 2 if they:
• Had no serious decline in health, as determined by their doctor, during the previous 14 days (including mental health).
• Have received at least 7.5 mg/kg AMB in Stage 1.
• Have a positive CSF culture for C. neoformans.
• Can take oral medications.

You may not qualify if…

• Patients will not be eligible for this study if they:
• Are in a coma.
• Are pregnant or breast-feeding.
• Are not using effective birth control methods, if able to have children.
• Are allergic to imidazole or triazole.
• Are allergic to rIFN-gamma 1b.
• Require drugs that are toxic to the kidneys, other than AMB.
• Received erythropoietin or red blood cell transfusions within 4 weeks of entering the study.
• Are receiving systemic corticosteroid therapy within 30 days of study or will require it during the study.
• Have had serious heart disease.
• Have had multiple sclerosis, peripheral vascular disease, or rheumatologic disorders.
• Have had disorders of the central nervous system (CNS) (not including emotional problems) or a seizure disorder, or have a current CNS disorder that would interfere with the study.
• Are receiving investigational therapy for C. neoformans within 90 days of starting the study drug.
• Have had more than 3 doses of AMB or more than 1200 mg of fluconazole or itraconazole as prior treatment and have begun current treatment for more than 72 hours prior to starting study medication. Fluconazole or itraconazole of no more than 200 mg daily is allowed.
• Are receiving AMB for C. neoformans within 30 days of starting treatment for the present episode.
• Are receiving rIFN-gamma 1b treatment within 90 days prior to starting the study drug.
• Have had therapy which affects the immune system within 30 days prior to starting the study drug.
• Are receiving investigational therapy for all other signs within 30 days prior to starting the study drug.
• Are not able to meet the study requirements, in the opinion of the investigator.
• Require chronic treatment with H2-blockers, and are able to receive only itraconazole in Stage 2.
• Show signs of or get treatment for another serious opportunistic infection within 4 weeks of starting the study drug.

Where it is running

• Univ of Alabama at Birmingham — Birmingham, Alabama, United States
• Washington Univ — St Louis, Missouri, United States
• UMDNJ - New Jersey Med School / Cooper Hosp — Camden, New Jersey, United States
• Univ of Med & Dentistry of New Jersey — Newark, New Jersey, United States
• Houston Veterans Administration Med Ctr — Houston, Texas, United States
• Univ of Texas / Med School at Houston — Houston, Texas, United States
• Audie L Murphy Veterans Administration Hosp — San Antonio, Texas, United States
• Hosp Nacional dos de Mayo — Lima, Peru
• Instituto de Medicina Tropical — Lima, Peru

Full record on ClinicalTrials.gov

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