Radiation Therapy and Cisplatin With or Without Amifostine for Patients With Stage IIIB or IVA Cervical Cancer
Completed · Phase 1/Phase 2
Conditions studied: Cervical Cancer, Radiation Toxicity
In brief
RATIONALE: Drugs used in chemotherapy, such as cisplatin, use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells. Drugs such as amifostine may protect normal cells from the side effects of radiation therapy. PURPOSE: Phase I/II trial to study the effectiveness of combining cisplatin and radiation therapy with or without amifostine in treating patients who have stage IIIB or stage IVA cancer of the cervix.
Key facts
- Study ID
- NCT00012012
- Run by
- Radiation Therapy Oncology Group
- People needed
- 45
- Starts
- 2001-08-01
- Expected to finish
- 2010-06-01
- Last updated by the study team
- 2015-01-07
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Baptist Cancer Institute - Jacksonville — Jacksonville, Florida, United States
- Florida Oncology Associates at Southside Cancer Center — Jacksonville, Florida, United States
- Integrated Community Oncology Network — Jacksonville Beach, Florida, United States
- Baptist Medical Center South — Jascksonville, Florida, United States
- Florida Oncology Associates — Orange Park, Florida, United States
- Florida Cancer Center - Palatka — Palatka, Florida, United States
- Flagler Cancer Center — Saint Augustine, Florida, United States
- West Michigan Cancer Center — Kalamazoo, Michigan, United States
- Bronson Methodist Hospital — Kalamazoo, Michigan, United States
- Borgess Medical Center — Kalamazooaa, Michigan, United States
- University Medical Center of Southern Nevada — Las Vegas, Nevada, United States
- CCOP - Nevada Cancer Research Foundation — Las Vegas, Nevada, United States
- Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton — Marlton, New Jersey, United States
- Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare — Vineland, New Jersey, United States
- Akron City Hospital — Akron, Ohio, United States
- Cancer Treatment Center — Wooster, Ohio, United States
- Mercy Cancer Institute at Mercy Hospital — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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