Genetic Analysis of Familial Brain Aneurysms
Completed
Conditions studied: Intracranial Aneurysm
In brief
This study will investigate cerebral (brain) aneurysms and their possible inheritance patterns in families. It will try to determine how often brain aneurysms occur in families in which more than one member has had an aneurysm and to find the gene or genes that contribute to their development. People in families in which more than one family member had a cerebral aneurysm are eligible for this 1-day study. They will undergo the following procedures: * Blood will be drawn (no more than 3 to 4 tablespoons) for research to identify genes that contribute to the development of brain aneurysms. * A magnetic resonance angiograph (MRA) scan will be done to examine a specific brain area where aneurysms typically occur. Magnetic resonance imaging uses a strong magnetic field and radio waves to produce images of the brain and detect abnormalities. If a more detailed picture of the brain is needed than can be obtained with MRA, a more specific MRA scan will be done using a contrast dye to enhance the images. Patients may be invited to participate in related NIH research studies.
Key facts
- Study ID
- NCT00011856
- Run by
- National Human Genome Research Institute (NHGRI)
- People needed
- 300
- Starts
- 2001-02-01
- Expected to finish
- 2002-03-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participants and their relatives that are affected or at a higher risk for cerebral aneurysms will be enrolled in this protocol.
You may not qualify if…
- For the MR Angiograph portion of the study, any participant that is not able to sign the Clinical Center consent form due to metal implants, pregnancy, claustrophobia, or an allergy to gadolinium as a contrast will be excluded from the imaging part of the study.
Where it is running
- National Human Genome Research Institute (NHGRI) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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