Mechanisms of Inflammatory Liver Injury

Completed

Conditions studied: Liver Diseases

In brief

White blood cells can cause liver damage if they inappropriately accumulate in the liver in large numbers. Such an event can occur if an individual's blood is exposed to endotoxin, a substance released from the cell walls of many species of bacteria. The purpose of this study is to isolate neutrophils, an important white blood cell, from the blood of normal volunteers, and put them in tissue culture with isolated liver cells. The experiments will determine how endotoxin can increase the ability of neutrophils to damage liver cells. All studies supported by this grant will be done with isolated cells in tissue culture. This experimental model will reveal possible mechanisms that can in the future be evaluated in human diseases such as bacterial sepsis.

Key facts

Study ID
NCT00011284
Run by
National Institute of Environmental Health Sciences (NIEHS)
People needed
50
Expected to finish
2001-11-01
Last updated by the study team
2005-06-24

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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