Ginkgo Biloba Prevention Trial in Older Individuals

Completed · Phase 3 · Has a placebo group

Conditions studied: Dementia, Alzheimer's Disease

In brief

This study will determine the effect of 240mg/day Ginkgo biloba in decreasing the incidence of dementia and specifically Alzheimer's disease (AD), slowing cognitive decline and functional disability, reducing incidence of cardiovascular disease, and decreasing total mortality.

Key facts

Study ID

NCT00010803

Run by

National Center for Complementary and Integrative Health (NCCIH)

People needed

3069

Starts

2000-10-01

Expected to finish

2011-07-01

Last updated by the study team

2013-03-14

Who can join

Age: 75 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Non-demented participants
• Willing to participate in a seven-year follow-up trial of Ginkgo Biloba
• English is their usual language
• Willing informant who has frequent contact with the participant

You may not qualify if…

• Currently on anticoagulant therapy
• Cancer diagnosed and treated within the past two years (except for skin cancer)
• Participant with class III - IV congestive heart failure
• Currently being treated with psychopharmacological drugs for depression
• Hospitalized for depression within the last year
• Taking Aricept (or similar agents) for cognitive problems or dementia
• Baseline blood creatinine >2
• Baseline SGGT is a marker of liver function (3 x normal>or=90 IU)
• Baseline hematocrit<30
• Baseline white blood count>or=15,000

Where it is running

• University of California, Davis — Sacramento, California, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Wake Forest University School of Medicine — Winston-Salem, North Carolina, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• University of Pittsburgh/University of Virginia — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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