Brain Imaging in Children With AD/HD

Completed

Conditions studied: Attention Deficit Disorder With Hyperactivity, Healthy

In brief

The purpose of this study is to use brain imaging technology to study the connections between brain regions in children with attention deficit hyperactivity disorder (AD/HD), and comparing them to children without AD/HD. This study will build upon previous brain imaging studies of healthy volunteers and children who have AD/HD. This study will use diffusion tensor magnetic resonance imaging (DT-MRI) to visualize and measure certain parts of the brains of identical twin pairs in which one twin has AD/HD, combined type. Participants in this study will be screened with questionnaires and interviews, psychometric testing, and a physical examination. Participants' medical and educational records may be reviewed. Participants will undergo an MRI scan of the brain. Prior to the MRI, participants will have a training session in a simulated MRI scanner to learn how to lie still during MRI scanning. Participants may be asked to return for a follow-up scan in about 2 years.

Key facts

Study ID

NCT00008892

Run by

National Institute of Mental Health (NIMH)

People needed

120

Starts

2001-01-12

Expected to finish

2007-01-31

Last updated by the study team

2017-07-02

Who can join

Age: 6 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• ADHD PROBANDS:
• Presence of other psychiatric disorders that can produce symptoms similar to ADHD (e.g., major depression, bipolar disorder, severe anxiety disorders, pervasive developmental disorders, psychotic disorders, post-traumatic stress disorder).
• Presence of neuropsychiatric conditions that may confound evaluation of ADHD (e.g., Tourette's syndrome, obsessive-compulsive disorder, or PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus).
• Presence of metal objects, pregnancy, or inability to provide a specimen of urine or blood to rule out pregnancy in females over age 12.
• Presence of alcohol and/or other substance abuse.
• NORMAL PEDIATRIC VOLUNTEERS:
• Presence of any psychiatric disorders on structured psychiatric interview (DICA-IV).
• Presence of known genetic conditions.
• Presence or history of medical conditions.
• Presence of metal objects, pregnancy, or inability to provide a specimen to rule out pregnancy in females over age 12.
• Presence of alcohol and/or other substance abuse.

Where it is running

• National Institute of Mental Health (NIMH), 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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