To Determine if Olanzapine is More Cost Effective Than Haloperidol for the Treatment of Schizophrenia

Completed · Phase 4

Conditions studied: Schizoaffective Disorder, Schizophrenia

In brief

Although currently marketed antipsychotic drugs are useful in the treatment of schizophrenia, efficacy and safety profiles need to be improved. Forty to eighty percent of patients either fail to respond or only partially respond to conventional antipsychotic agents. Secondary symptoms may be unimproved even in patients who respond to treatment. A variety of adverse events occur in patients receiving currently available agents. The severity of these events contributes to the poor compliance that is observed in this patient population. Olanzapine is a novel antipsychotic agent with a reduced incidence of extrapyramidal symptoms. Other side effects are minimal.

Key facts

Study ID

NCT00007774

Run by

US Department of Veterans Affairs

People needed

600

Starts

1998-03-01

Last updated by the study team

2009-02-04

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with schizophrenia or schizoaffective disorder.

Where it is running

• VA Medical Center, Tuscaloosa — Tuscaloosa, Alabama, United States
• VA Palo Alto Health Care System — Palo Alto, California, United States
• VA Connecticut Health Care System (West Haven) — West Haven, Connecticut, United States
• VA Medical Center, Bay Pines — Bay Pines, Florida, United States
• VA Medical Center, Miami — Miami, Florida, United States
• VA Medical Center, Augusta — Augusta, Georgia, United States
• Richard Roudebush VA Medical Center, Indianapolis — Indianapolis, Indiana, United States
• VA Maryland HCS, Perry Point Division — Perry Point, Maryland, United States
• Edith Nourse Rogers Memorial Veterans Hospital, Bedford — Bedford, Massachusetts, United States
• John D. Dingell VA Medical Center, Detroit — Detroit, Michigan, United States
• VA New Jersey Health Care System, East Orange — East Orange, New Jersey, United States
• New Mexico VA Health Care System, Albuquerque — Albuquerque, New Mexico, United States
• Franklin Delano Roosevelt Campus, VA Hudson Valley HCS — Montrose, New York, United States
• New York Harbor HCS — New York, New York, United States
• VA Medical Center, Durham — Durham, North Carolina, United States
• VA Medical Center, Cleveland — Cleveland, Ohio, United States
• VA Medical Center, Philadelphia — Philadelphia, Pennsylvania, United States
• VA Pittsburgh Health Care System — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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