Warfarin and Antiplatelet Therapy in Chronic Heart Failure

Completed · Phase 3

Conditions studied: Heart Failure

In brief

Whether patients with chronic heart failure (CHF) should be anticoagulated is one of the oldest unresolved questions in cardiovascular therapeutics. Some authorities do not recommend anticoagulation for CHF patients in sinus rhythm, others recommend anticoagulation in patients with primary cardiomyopathy, and still others consider it more appropriate in patients with coronary artery disease (CAD). This absence of consensus reflects the lack of evidence in this area and different outlooks on the objectives of such therapy (e.g., prevention of arterial emboli or reduction in vascular events).

Key facts

Study ID

NCT00007683

Run by

US Department of Veterans Affairs

People needed

1587

Starts

1998-10-01

Expected to finish

2004-12-01

Last updated by the study team

2011-06-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion Criteria:
• Patients with NYHA class II, III, or IV and left ventricular ejection fractions less than or equal to 35%, on an ACE inhibitor (unless not tolerated) and on a diuretic.

Where it is running

• Carl T. Hayden VA Medical Center — Phoenix, Arizona, United States
• Southern Arizona VA Health Care System, Tucson — Tucson, Arizona, United States
• Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock — No. Little Rock, Arkansas, United States
• Rancho Los Amigos National Rehabilitation Center — Downey, California, United States
• VA Central California Health Care System, Fresno — Fresno, California, United States
• VA Medical Center, Loma Linda — Loma Linda, California, United States
• VA Palo Alto Health Care System — Palo Alto, California, United States
• VA Medical Center, San Francisco — San Francisco, California, United States
• VA Greater Los Angeles HCS, Sepulveda — Sepulveda, California, United States
• Cardiovascular Consultants, Walnut Creek — Walnut Creek, California, United States
• VA Greater Los Angeles Healthcare System, West LA — West Los Angeles, California, United States
• VA Eastern Colorado Health Care System, Denver — Denver, Colorado, United States
• Cardiology Associates of Derby, P.C. — Derby, Connecticut, United States
• St. Francis Hospital and Medical Center — Hartford, Connecticut, United States
• VA Connecticut Health Care System (West Haven) — West Haven, Connecticut, United States
• VA Medical Center, DC — Washington D.C., District of Columbia, United States
• Florida Cardiovascular Research — Atlantis, Florida, United States
• VA Medical Center, Bay Pines — Bay Pines, Florida, United States
• North Florida/South Georgia Veterans Health System — Gainesville, Florida, United States
• Watson Clinic LLP — Lakeland, Florida, United States
• Brevard Cardiology — Merritt Island, Florida, United States
• VA Medical Center, Miami — Miami, Florida, United States
• Cardiology Consultants - Pensacola — Pensacola, Florida, United States
• University Cardiology Consultants — Tamarac, Florida, United States
• VA Medical Center, Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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