Does Gabapentin and Lamotriginel Have Significantly Fewer Side-effects While Providing Equal or Better Seizure Control Than the Current Drug Choice, Carbamazepine, for the Treatment of Seizures in the Elderly.
Completed · Phase 3
Conditions studied: Seizures
In brief
New onset epilepsy in the elderly occurs in 45,000-50,000 elderly patients each year. These patients are especially vulnerable to side effects from medications because of changes caused by the aging process and the fact that these patients often have many common diseases for which they are already receiving medications for so that the likelihood of drug interactions is increased. Two new drugs, gabapentin and lamotrigine, have recently been approved by the FDA as antiepileptic drugs. These drugs have demonstrated efficacy in the treatment of partial onset seizures, the most common seizures in the elderly. These new compounds also have favorable side effect profiles and infrequent drug-drug interactions and, therefore, would be expected to be well-tolerated in the elderly.
Key facts
- Study ID
- NCT00007670
- Run by
- US Department of Veterans Affairs
- People needed
- 720
- Starts
- 1998-01-01
- Expected to finish
- 2003-03-01
- Last updated by the study team
- 2023-10-30
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Birmingham VA Medical Center — Birmingham, Alabama, United States
- Carl T. Hayden VA Medical Center — Phoenix, Arizona, United States
- Vamc - West Los Angeles, Los Angeles, Ca — Los Angeles, California, United States
- Vamc - San Diego, San Diego, Ca — San Diego, California, United States
- San Francisco VAMC — San Francisco, California, United States
- Denver VA Medical Center — Denver, Colorado, United States
- Vamc - Bay Pines, Fl — Bay Pines, Florida, United States
- Gainesville VA Medical Center — Gainesville, Florida, United States
- Miami VA Medical Center — Miami, Florida, United States
- Study Chairperson — Miami, Florida, United States
- Chicago VA Medical Center (West Side) — Chicago, Illinois, United States
- Edward Hines Jr. VA Hospital — Hines, Illinois, United States
- New Orleans VAMC — New Orleans, Louisiana, United States
- Boston VA Medical Center — Boston, Massachusetts, United States
- Bronx VA Medical Center — The Bronx, New York, United States
- Study Chairman — The Bronx, New York, United States
- Oklahoma City VA Medical Center — Oklahoma City, Oklahoma, United States
- Vamc - Pittsburgh, Pittsburgh, Pa — Pittsburgh, Pennsylvania, United States
- Dallas VA Medical Center — Dallas, Texas, United States
- Hunter Holmes McGuire VA Medical Center — Richmond, Virginia, United States
Full record on ClinicalTrials.gov
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