Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation

Completed · Phase 3

Conditions studied: Myocardial Ischemia

In brief

PCI (optimal catheter-based coronary revascularization) + intensive medical therapy is superior to intensive medical therapy alone using the combined endpoint of all-cause mortality or nonfatal MI.

Key facts

Study ID

NCT00007657

Run by

US Department of Veterans Affairs

People needed

3260

Starts

1998-12-01

Expected to finish

2006-06-01

Last updated by the study team

2009-06-15

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients eligible for inclusion in COURAGE will comprise all but very high-risk subjects, and will include those with chronic angina pectoris (Canadian Cardiovascular Society [CCS] Class I-III), uncomplicated MI, cooled down ACS, and asymptomatic (or "silent") myocardial ischemia.
• Patients may have single- or multi-vessel coronary artery disease and may have had prior bypass graft surgery or PCI.
• It is important to emphasize that as many types of CAD patients as possible--reflecting the spectrum of patients encountered in contemporary clinical practice--will be enrolled in COURAGE.

Where it is running

• Mayo Clinic Arizona — Scottsdale, Arizona, United States
• Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock — No. Little Rock, Arkansas, United States
• Southern CA Kaiser Permanente Medical Group — Los Angeles, California, United States
• VA Northern California HCS — Sacramento, California, United States
• Hartford Hospital — Hartford, Connecticut, United States
• Christiana Care Health Systems-Newark, DE — Newark, Delaware, United States
• MIMA Century Research Associates - Melbourne, FL — Melbourne, Florida, United States
• James A. Haley Veterans Hospital, Tampa — Tampa, Florida, United States
• Atlanta VA Medical and Rehab Center, Decatur — Decatur, Georgia, United States
• Jesse Brown VAMC (WestSide Division) — Chicago, Illinois, United States
• Genesis Medical Center — Davenport, Iowa, United States
• VA Medical Center, Iowa City — Iowa City, Iowa, United States
• VA Medical Center, Lexington — Lexington, Kentucky, United States
• VA Maryland Health Care System, Baltimore — Baltimore, Maryland, United States
• VA Medical Center, Jamaica Plain Campus — Boston, Massachusetts, United States
• VA Ann Arbor Healthcare System — Ann Arbor, Michigan, United States
• John D. Dingell VA Medical Center, Detroit — Detroit, Michigan, United States
• Mayo Clinic Rochester - Rochester, MN — Rochester, Minnesota, United States
• VA Medical Center, Kansas City MO — Kansas City, Missouri, United States
• VA Medical Center, St Louis — St Louis, Missouri, United States
• New Mexico VA Health Care System, Albuquerque — Albuquerque, New Mexico, United States
• New York Harbor HCS — New York, New York, United States
• University of Rochester Strong Memorial Hospital — Rochester, New York, United States
• VA Medical Center, Syracuse — Syracuse, New York, United States
• VA Medical Center, Durham — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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