Comparing the Effects of Amiodarone, Sotalol, and Placebo in Maintaining Sinus Rhythm in Patients With Atrial Fibrillation Converted to Sinus Rhythm

Completed · Phase 3

Conditions studied: Atrial Fibrillation, Cerebrovascular Accident, Death, Sudden

In brief

Atrial fibrillation is the most frequently occurring cardiac arrhythmia, with 1.0-1.5 million cases annually. It is a risk factor for congestive heart failure, and stroke, 75,000 cases of the latter occurring annually in patients with atrial fibrillation. The safety of the most widely used antiarrhythmic agent for this group of patients, quinidine, has been called into question. This study seeks to determine whether two other agents, amiodarone and sotalol, are safe and effective treatments for patients with atrial fibrillation.

Key facts

Study ID

NCT00007605

Run by

US Department of Veterans Affairs

People needed

706

Starts

1998-04-01

Expected to finish

2003-12-01

Last updated by the study team

2011-06-15

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who have atrial fibrillation continuously for greater than 72 hours.

Where it is running

• Southern Arizona VA Health Care System, Tucson — Tucson, Arizona, United States
• Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock — No. Little Rock, Arkansas, United States
• VA Central California Health Care System, Fresno — Fresno, California, United States
• VA Medical Center, Loma Linda — Loma Linda, California, United States
• VA Palo Alto Health Care System — Palo Alto, California, United States
• VA Greater Los Angeles HCS, Sepulveda — Sepulveda, California, United States
• VA Greater Los Angeles Healthcare System, West LA — West Los Angeles, California, United States
• VA Connecticut Health Care System (West Haven) — West Haven, Connecticut, United States
• VA Medical Center, DC — Washington D.C., District of Columbia, United States
• VA Medical Center, Bay Pines — Bay Pines, Florida, United States
• James A. Haley Veterans Hospital, Tampa — Tampa, Florida, United States
• VA Medical Center, Augusta — Augusta, Georgia, United States
• Edward Hines, Jr. VA Hospital — Hines, Illinois, United States
• VA Medical Center, Iowa City — Iowa City, Iowa, United States
• VA Boston Healthcare System, Brockton Campus — Brockton, Massachusetts, United States
• VA Medical Center, Minneapolis — Minneapolis, Minnesota, United States
• VA Medical Center, Kansas City MO — Kansas City, Missouri, United States
• VA Medical Center, St Louis — St Louis, Missouri, United States
• New Mexico VA Health Care System, Albuquerque — Albuquerque, New Mexico, United States
• VA Medical Center, Fargo — Fargo, North Dakota, United States
• VA Medical Center, Portland — Portland, Oregon, United States
• VA Pittsburgh Health Care System — Pittsburgh, Pennsylvania, United States
• VA Medical Center, Providence — Providence, Rhode Island, United States
• VA Medical Center, Memphis — Memphis, Tennessee, United States
• VA Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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