Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)

Completed · Phase 3

Conditions studied: Alzheimer Disease

In brief

The purpose of this trial is to test the ability of the non-steroidal anti-inflammatory medications naproxen and celecoxib to delay or prevent the onset of AD and age-related cognitive decline.

Key facts

Study ID

NCT00007189

Run by

Seattle Institute for Biomedical and Clinical Research

People needed

2625

Starts

2001-01-01

Last updated by the study team

2016-10-19

Who can join

Age: 70 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 70 years or older.
• Family history of parent, brother, or sister who has, or had, serious age-related memory loss, senility, dementia, or Alzheimer's disease.
• Study partner available to provide information on the cognitive status of the participant and to assist with monitoring of trial medications, if needed.
• Sufficient fluency in written and spoken English to participate in study visits and neuropsychological testing.
• Willingness to limit use of the following for the duration of the study: vitamin E (at doses greater than 400 IU per day), non-aspirin NSAIDs, histamine H2 receptor antagonists (Tagamet, for example), corticosteroids, anti-inflammatory or analgesic doses of aspirin (greater than 81 mg per day), Ginkgo biloba extracts
• Ability and intention to participate in regular study visits, in the opinion of the study physician.
• Provision of informed consent.

You may not qualify if…

• History of peptic ulcer disease with bleeding or obstruction.
• Clinically significant liver or kidney disease.
• History of hypersensitivity to aspirin, ibuprofen, celecoxib, naproxen, or other NSAIDs.
• Use of anti-coagulant medication.
• Cognitive impairment or dementia.
• Current alcohol abuse or dependence

Where it is running

• Sun Health Research Institute — Sun City, Arizona, United States
• Roskamp Institute Memory Clinic, 10770 N. 46th Street — Tampa, Florida, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Boston University School of Medicine — Boston, Massachusetts, United States
• University of Rochester — Rochester, New York, United States
• Veterans Affairs Puget Sound Health Care System, University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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